The third time turns out to be the charm for criminal Neal Caffrey. He has been eluding FBI agent Peter Burke for years, a run that finally comes to an end with his capture. But after the resourceful prisoner escapes from a maximum-security facility, then is nabbed once again by Burke, Caffrey suggests a different end-game: In return for freedom, he'll help the Feds catch long-sought criminals. Though skeptical, Burke soon realizes that Caffrey's instincts and insight are a rare commodity. Caffrey's trusted friend and co-conspirator with ties to the criminal underworld, Mozzie, also becomes a useful source for Burke and the FBI.